Bioaktive Oberflächenbeschichtung von bioinerter oxidischer Keramik zur Stimulation der Knochenanbindung


Bioactive surface coating of bioinert oxide ceramics to stimulate osteointegration

The aim of this research project is the production of ceramic implant materials with improved osteointegration. The improvement shall lead to a shortened post-operative healing phase and a solid and long-term integration to the adjacent bone tissue. Surface coating of ceramic implants will be achieved using "wet powder-spray coating" of yttrium stabilized zirconium oxide bioinert (TZ) with mixed suspension consisting of TZ, hydroxyapatite (HA) and magnesium oxide (MgO). The driving idea behind these coatings is that they consist of a solid and non-absorbable part (TZ) and partially absorbable and bioactive components (HA and Mg). this amalgam would provide sufficient biomechanical strength and the vital support of bone cells during healing and bone growth. Biocompatibility was proven through a comprehensive physicochemical and biological examination in vitro. In the current project, the in vivo characterization is being carried out. Here it is expected that the coated TZ-implants will reflect the in vitro results and exhibit enhanced bone formation in vivo, with an increased stability of the implant. The study will utilize an established animal model of rabbits to study biocompatibility and osteointegration. The bone formation will be evaluated histologically and histomorphometrically at the bone implant contact (BIC) region. Additionally biomechanical competence will be determined and compared to the non coated implant controls.



Projektleitung Dr. Thaqif El Khassawna
  Justus Liebig Universität Gießen
  Labor für experimentelle Unfallchirurgie
Weitere ProjektmitgliederUniv.-Professor Dr. med. Christian Heiß Direktor der Klinik und Poliklinik für Unfall-, Hand- und Wiederherstellungschirurgie - Operative Notaufnahme Universitätsklinikum Gießen und Marburg GmbH Rudolf-Buchheim-Straße 7, D-35385 Gießen Tel.: +49-(0)-641-98544601; Fax: +49-(0)-641-98544609 Labor für experimentelle Unfallchirurgie Justus-Liebig Universität Gießen Kerkraderstr. 9 35394 Gießen Tel.: 0641/9433-117 FAX: 0641/9433-119 E-Mail: URL:
Laufzeit des Projektes
Forschungsbereich Translationale Forschung